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Article

Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells.

American journal of physiology. Renal physiology - 1 Mar 2017

Wu Min, Zhang Jian-Dong, Tang Ri-Ning, Crowley Steven D, Liu Hong, Lv Lin-Li, Ma Kun-Ling, Liu Bi-Cheng

Abstract excerpt

Previous studies have shown that increased parathyroid hormone (PTH) attributable to secondary hyperparathyroidism in chronic kidney disease accelerates the arteriosclerotic fibrosis and calcification. Although the underlying mechanisms remain largely unknown, endothelial cells (ECs) have recently been demonstrated to participate in calcification in part by providing chondrogenic cells via the...

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Source

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Identifiers

PMID: 27582099
DOI: 10.1152/ajprenal.00210.2016
PMCID: PMC5374307

Genes

PTH
DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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