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Article

Enhancement of gene targeting in human cells by intranuclear permeation of the Saccharomyces cerevisiae Rad52 protein.

Nucleic acids research - 1 Aug 2010

Kalvala Arjun, Rainaldi Giuseppe, Di Primio Cristina, Liverani Vania, Falaschi Arturo, Galli Alvaro

Abstract excerpt

The introduction of exogenous DNA in human somatic cells results in a frequency of random integration at least 100-fold higher than gene targeting (GT), posing a seemingly insurmountable limitation for gene therapy applications. We previously reported that, in human cells, the stable over-express...

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Source

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Identifiers

PMID: 20519199
DOI: 10.1093/nar/gkq486
PMCID: PMC2919737

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TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20519199-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Enhancement of gene targeting in human cells by intranuclear permeation of the Saccharomyces cerevisiae Rad52 protein.PMID 20519199Read ↗

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