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Article

RAD51 loss of function abolishes gene targeting and de-represses illegitimate integration in the moss Physcomitrella patens.

DNA repair - 4 May 2010

Schaefer D G, Delacote F, Charlot F, Vrielynck N, Guyon-Debast A, Le Guin S, Neuhaus J M, Doutriaux M P, Nogué F

Abstract excerpt

Gene targeting (GT) is a major tool for basic and applied research during which the transforming DNA, which shares sequence homology with a chromosomal target, integrates at the corresponding locus by homologous recombination (HR). In eukaryotes, GT recruits enzymes from the HR-mediated double strand break repair pathway. Different mechanisms of HR have been described which depend on the Rad52 epistasis group of...

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Source

Identifiers

PMID: 20189889
DOI: 10.1016/j.dnarep.2010.02.001

Genes

RAD51
RAD52

Provenance

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Related research

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RAD51 loss of function abolishes gene targeting and de-represses illegitimate integration in the moss Physcomitrella patens.PMID 20189889Read ↗

Differential requirements for RAD51 in Physcomitrella patens and Arabidopsis thaliana development and DNA damage repair.Semantic proximity Read ↗

MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens.Semantic proximity Read ↗

The Arabidopsis RAD51 paralogs RAD51B, RAD51D and XRCC2 play partially redundant roles in somatic DNA repair and gene regulation.Semantic proximity Read ↗

Homologous recombination in planta is stimulated in the absence of Rad50.Semantic proximity Read ↗

The Importance of ATM and ATR in Physcomitrella patens DNA Damage Repair, Development, and Gene Targeting.Semantic proximity Read ↗

Efficient gene targeting in the moss Physcomitrella patens.Semantic proximity Read ↗

RAD51B plays an essential role during somatic and meiotic recombination in Physcomitrella.Semantic proximity Read ↗

Non-homologous end-joining proteins are required for Agrobacterium T-DNA integration.Semantic proximity Read ↗

Genetic requirements for the targeted integration of Agrobacterium T-DNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Moss BRCA2 lacking canonical DNA binding domain promotes efficient homologous recombination and binds to DNASemantic proximity Read ↗

Effects of XRCC2 and RAD51B mutations on somatic and meiotic recombination in Arabidopsis thaliana.Semantic proximity Read ↗

DNA repair genes RAD52 and SRS2, a cell wall synthesis regulator gene SMI1, and the membrane sterol synthesis scaffold gene ERG28 are important in efficient Agrobacterium-mediated yeast transformation with chromosomal T-DNA.Semantic proximity Read ↗

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