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Article

Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo.

Nucleic acids research - 1 Jan 2004

Liu Li, Maguire Katie K, Kmiec Eric B

Abstract excerpt

Oligonucleotides can be used to direct the alteration of single nucleotides in chromosomal genes in yeast. Rad51 protein appears to play a central role in catalyzing the reaction, most likely through its DNA pairing function. Here, we re-engineer the RAD51 gene in order to produce proteins bearin...

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Identifiers

PMID: 15087488
DOI: 10.1093/nar/gkh506
PMCID: PMC407811

Genes

RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15087488-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo.PMID 15087488Read ↗

Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors.Semantic proximity Read ↗

Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes.Semantic proximity Read ↗

Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair.Semantic proximity Read ↗

Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2.Semantic proximity Read ↗

Homologous recombination is essential for RAD51 up-regulation in Saccharomyces cerevisiae following DNA crosslinking damage.Semantic proximity Read ↗

Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides.Semantic proximity Read ↗

RAD51 loss of function abolishes gene targeting and de-represses illegitimate integration in the moss Physcomitrella patens.Semantic proximity Read ↗

Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54.Semantic proximity Read ↗

RAD59 and RAD1 cooperate in translocation formation by single-strand annealing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Specific negative effects resulting from elevated levels of the recombinational repair protein Rad54p in Saccharomyces cerevisiae.Semantic proximity Read ↗

In vitro and in vivo nucleotide exchange directed by chimeric RNA/DNA oligonucleotides in Saccharomyces cerevisae.Semantic proximity Read ↗

Mutations in RAD3, MSH2, and RAD52 affect the rate of gene amplification in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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