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Article

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Jun 2010

Leung Daisy W, Borek Dominika, Farahbakhsh Mina, Ramanan Parameshwaran, Nix Jay C, Wang Tianjiao, Prins Kathleen C, Otwinowski Zbyszek, Honzatko Richard B, Helgeson Luke A, Basler Christopher F, Amarasinghe Gaya K

Abstract excerpt

VP35 is one of seven structural proteins encoded by the Ebola viral genome and mediates viral replication, nucleocapsid formation and host immune suppression. The C-terminal interferon inhibitory domain (IID) of VP35 is critical for dsRNA binding and interferon inhibition. The wild-type VP35 IID structure revealed several conserved residues that are important for dsRNA binding and interferon antagonism. Here, the...

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Identifiers

PMID: 20516601
DOI: 10.1107/S1744309110013266
PMCID: PMC2882771

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