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Article

dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35.

Antiviral research - 1 Mar 2012

Zinzula Luca, Esposito Francesca, Pala Daniela, Tramontano Enzo

Abstract excerpt

The Ebola viruses (EBOVs) VP35 protein is a multifunctional major virulence factor involved in EBOVs replication and evasion of the host immune system. EBOV VP35 is an essential component of the viral RNA polymerase, it is a key participant of the nucleocapsid assembly and it inhibits the innate immune response by antagonizing RIG-I like receptors through its dsRNA binding function and, hence, by suppressing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22289166
DOI: 10.1016/j.antiviral.2012.01.005
PMCID: PMC7114247

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dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35.PMID 22289166Read ↗

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