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Exploration micromechanism of VP35 IID interaction and recognition dsRNA: A molecular dynamics simulation.

Proteins - 1 Jun 2017

Zhang Yan-Jun, Ding Jing-Na, Zhong Hui, Han Ju-Guang

Abstract excerpt

Multifunctional viral protein (VP35) encoded by the highly pathogenic Ebola viruses (EBOVs) can antagonize host double-stranded RNA (dsRNA) sensors and immune response because of the simultaneous recognition of dsRNA backbone and blunt ends. Mutation of select hydrophobic conserved basic residues within the VP35 inhibitory domain (IID) abrogates its dsRNA-binding activity, and impairs VP35-mediated interferon...

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Alanine
Ebolavirus
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Interaction Domains and Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Double-Stranded

Static Electricity

Viral Regulatory and Accessory Proteins

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PMID: 28205249
DOI: 10.1002/prot.25269

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