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Article

DRBP76 Associates With Ebola Virus VP35 and Suppresses Viral Polymerase Function

10 Oct 2011

Abstract excerpt

The Zaire Ebola virus (EBOV) protein VP35 is multifunctional; it inhibits IFN-α/β production and functions as a cofactor of the viral RNA polymerase. Mass spectrometry identified the double stranded RNA binding protein 76 (DRBP76/NFAR-1/NF90) as a cellular factor that associates with the VP35 C-terminal interferon inhibitory domain (IID). DRBP76 is described to regulate host cell protein synthesis and play an...

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Mosquito-borne diseases and control
Viral Infections and Outbreaks Research
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21987769
DOI: 10.1093/infdis/jir343

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