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Article

Keratinocyte-targeted overexpression of the glucocorticoid receptor delays cutaneous wound healing.

PloS one - 1 Jan 2012

Sanchis Ana, Alba Lorena, Latorre Víctor, Sevilla Lisa M, Pérez Paloma

Abstract excerpt

Delayed wound healing is one of the most common secondary adverse effects associated to the therapeutic use of glucocorticoid (GC) analogs, which act through the ligand-dependent transcription factor GC-receptor (GR). GR function is exerted through DNA-binding-dependent and -independent mechanisms, classically referred to as transactivation (TA) and transrepression (TR). Currently both TA and TR are thought to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22235328
DOI: 10.1371/journal.pone.0029701
PMCID: PMC3250471

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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