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Telomeres and Thyroid Cancer

29 Sept 2009

Abstract excerpt

Telomeres are specialized structures at the ends of chromosomes, consisting of hundreds of repeated hexanucleotides (TTAGGG)n. Genetic integrity is partly maintained by the architecture of telomeres and it is gradually lost as telomeres progressively shorten with each cell replication, due to incomplete lagging DNA strand synthesis and oxidative damage. Telomerase is a reverse transcriptase enzyme that...

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PMID: 20514214
DOI: 10.2174/138920209789503897

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