Article
Short telomeres, telomerase reverse transcriptase gene amplification, and increased telomerase activity in the blood of familial papillary thyroid cancer patients.
The Journal of clinical endocrinology and metabolism - 1 Oct 2008
Capezzone Marco, Cantara Silvia, Marchisotta Stefania, Filetti Sebastiano, De Santi Maria Margherita, Rossi Benedetta, Ronga Giuseppe, Durante Cosimo, Pacini Furio
Abstract excerpt
BACKGROUND: Differentiated papillary thyroid cancer is mostly sporadic, but the recurrence of the familial form has been reported. Short or dysfunctional telomeres have been associated with familial benign diseases and familial breast cancer. OBJECTIVE: The aim of our work was to study the telomere-telomerase complex in the peripheral blood of patients with familial papillary thyroid cancer (FPTC), including the...
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