Article
Targeting plasma cells improves detection of cytogenetic aberrations in multiple myeloma: phenotype/genotype fluorescence in situ hybridization.
Cancer genetics and cytogenetics - 15 Apr 2005
Slovak Marilyn L, Bedell Victoria, Pagel Kristen, Chang Karen L, Smith David, Somlo George
Abstract excerpt
Standard fluorescence in situ hybridization (FISH) easily detects nonrandom karyotypic abnormalities in multiple myeloma (MM) at disease presentation, when tumor burden is high. In contrast, the detection of residual MM using the standard 200 unselected nonmitotic nuclei FISH approach correlates poorly with residual disease detected by morphology, flow cytometry, immunohistochemistry, or reverse-transcription...
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