Article
Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL).
Clinica chimica acta; international journal of clinical chemistry - 6 Sept 2010
Demacq Caroline, Vasconcellos Vivian B, Izidoro-Toledo Tatiane C, da Silva Silveira Vanessa, Canalle Renata, Queiroz Rosane Gomes de Paula, Tone Luiz Gonzaga, Tanus-Santos Jose E
Abstract excerpt
BACKGROUND: Angiogenesis has been shown as an important process in hematological malignancies. It consists in endothelial proliferation, migration, and tube formation following pro-angiogenic factors releasing, specially the vascular endothelial growth factor (VEGF), which angiogenic effect seems to be dependent on nitric oxide (NO). We examined the association among functional polymorphisms in these two...
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