Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nucleotide excision repair polymorphisms and survival outcome for patients with metastatic breast cancer.

Journal of cancer research and clinical oncology - 1 Mar 2011

Bewick Mary A, Lafrenie Robert M, Conlon Michael S C

Abstract excerpt

PURPOSE: Inter-individual variations in treatment efficacy may be influenced by polymorphisms in DNA repair genes. We investigated the association of 3 functional polymorphisms in the nucleotide excision repair (NER) pathway with survival outcome of 95 patients with metastatic breast cancer (MBC) treated with DNA-damaging chemotherapy. METHODS: ERCC1 8092 C/A, ERCC2 Asp312Asn and ERCC2 Lys751Gln were determined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to Endonucleases

Share to Survival Rate

Share to Treatment Outcome

Share to Xeroderma Pigmentosum Group D Protein

Source

Identifiers

PMID: 20508946
DOI: 10.1007/s00432-010-0915-7

Genes

ERCC2
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleotide excision repair polymorphisms and survival outcome for patients with metastatic breast cancer.PMID 20508946Read ↗

Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer.Semantic proximity Read ↗

Role of XRCC3, XRCC1 and XPD single-nucleotide polymorphisms in survival outcomes following adjuvant chemotherapy in early stage breast cancer patients.Semantic proximity Read ↗

Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer.Semantic proximity Read ↗

Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer.Semantic proximity Read ↗

Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival.Semantic proximity Read ↗

DNA-repair gene polymorphisms predict favorable clinical outcome among patients with advanced squamous cell carcinoma of the head and neck treated with cisplatin-based induction chemotherapy.Semantic proximity Read ↗

Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependent.Semantic proximity Read ↗

Base excision repair factors are promising prognostic and predictive markers in cancer.Semantic proximity Read ↗

Association of MTHFR gene polymorphisms with breast cancer survival.Semantic proximity Read ↗

Impact of genetic variability and treatment-related factors on outcome in early breast cancer patients receiving (neo-) adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide, and docetaxel.Semantic proximity Read ↗

Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT).Semantic proximity Read ↗

Acute myeloid leukemia outcome: role of nucleotide excision repair polymorphisms in intermediate risk patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.