Article
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
The Journal of biological chemistry - 29 May 2015
Norris Kristi L, Hao Rui, Chen Liang-Fu, Lai Chun-Hsiang, Kapur Meghan, Shaughnessy Peter J, Chou Dennis, Yan Jin, Taylor J Paul, Engelender Simone, West Anna E, Lim Kah-Leong, Yao Tso-Pang
Abstract excerpt
Mutations in PARKIN (PARK2), an ubiquitin ligase, cause early onset Parkinson disease. Parkin was shown to bind, ubiquitinate, and target depolarized mitochondria for destruction by autophagy. This process, mitophagy, is considered crucial for maintaining mitochondrial integrity and suppressing Parkinsonism. Here, we report that under moderate mitochondrial stress, parkin does not translocate to mitochondria to...
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