Article
A polymorphism in the AT-hook motif of the transcriptional regulator AKNA is a risk factor for cervical cancer.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Aug 2010
Perales Guillermo, Burguete-García Ana I, Dimas Jisela, Bahena-Román Margarita, Bermúdez-Morales Víctor H, Moreno José, Madrid-Marina Vicente
Abstract excerpt
The AKNA gene is part of the 9q32 susceptibility locus for cervical cancer. A single-nucleotide polymorphism at codon 1119 of AKNA, yields a biologically relevant amino acid change (R1119Q) at the DNA binding AT-hook motif. Genotype frequencies in 97 allele pairs were: R/R = 0.597, R/Q = 0.278, Q/Q = 0.123. Q/Q homozygosity was present in 8.33% of healthy controls, 16.67% of patients with cervical intraepithelial...
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