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Article

P53 expression as a prognostic marker in giant cell tumor of bone: a pilot study.

Orthopedics - 12 May 2010

Papanastassiou Ioannis, Ioannou Markos, Papagelopoulos Panayiotis J, Arealis George, Mihas Constantinos, Iakovidou Ioanna, Demertzis Nikolaos

Abstract excerpt

P53 is the best known tumor suppressor gene. If p53 is mutated, the ability of the cell to sense and repair DNA defects is lost. Failure of this mechanism increases the risk of malignant transformation and tumorigenesis. P53 overexpression is implicated in many carcinomas. P53 alterations appear to be frequent in bone and soft tissue sarcoma and have a strong negative impact on survival in various subtypes of...

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Identifiers

PMID: 20506947
DOI: 10.3928/01477447-20100329-15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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