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Article

p53 mutations may be involved in malignant transformation of giant cell tumor of bone through interaction with GPX1.

Virchows Archiv : an international journal of pathology - 1 Jul 2013

Okubo Taketo, Saito Tsuyoshi, Mitomi Hiroyuki, Takagi Tatsuya, Torigoe Tomoaki, Suehara Yoshiyuki, Kaneko Kazuo, Yao Takashi

Abstract excerpt

Giant cell tumor of bone (GCTB) is a benign tumor with a tendency for local recurrence. Secondary malignant GCTB is rare, occurring in less than 2 % of GCTB cases. Mechanisms of malignant transformation of GCTB remain unclear. We examined 43 cases of GCTB (38 conventional cases, two lung implanta...

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Share to Bone Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, p53

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Share to Glutathione Peroxidase GPX1

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Share to Loss of Heterozygosity

Source

Identifiers

PMID: 23748877
DOI: 10.1007/s00428-013-1435-z

Genes

GPX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23748877-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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