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Article

p53 mutations may be involved in malignant transformation of giant cell tumor of bone through interaction with GPX1.

Virchows Archiv : an international journal of pathology - 1 Jul 2013

Okubo Taketo, Saito Tsuyoshi, Mitomi Hiroyuki, Takagi Tatsuya, Torigoe Tomoaki, Suehara Yoshiyuki, Kaneko Kazuo, Yao Takashi

Abstract excerpt

Giant cell tumor of bone (GCTB) is a benign tumor with a tendency for local recurrence. Secondary malignant GCTB is rare, occurring in less than 2 % of GCTB cases. Mechanisms of malignant transformation of GCTB remain unclear. We examined 43 cases of GCTB (38 conventional cases, two lung implantation cases, and three secondary malignant cases) for p53 gene mutations and for loss of heterozygosity (LOH) of p53...

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Share to Bone Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, p53

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Share to Glutathione Peroxidase GPX1

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Source

Identifiers

PMID: 23748877
DOI: 10.1007/s00428-013-1435-z

Genes

GPX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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