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Article

The CD10 Enzyme Is a Key Player to Identify and Regulate Human Mammary Stem Cells

28 Apr 2010

Abstract excerpt

The major components of the mammary ductal tree are an inner layer of luminal cells, an outer layer of myoepithelial cells, and a basement membrane that separates the ducts from the underlying stroma. Cells in the outer layer express CD10, a zinc-dependent metalloprotease that regulates the growth of the ductal tree during mammary gland development. To define the steps in the human mammary lineage at which CD10...

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PMID: 20506111
DOI: 10.1002/stem.435

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