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Article

Striatal overexpression of DeltaFosB reproduces chronic levodopa-induced involuntary movements.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 May 2010

Cao Xuebing, Yasuda Toru, Uthayathas Subramaniam, Watts Ray L, Mouradian M Maral, Mochizuki Hideki, Papa Stella M

Abstract excerpt

Long-term dopamine replacement therapy in Parkinson's disease leads to the development of disabling involuntary movements named dyskinesias that are related to adaptive changes in striatal signaling pathways. The chronic transcription factor DeltaFosB, which is overexpressed in striatal neurons after chronic dopaminergic drug exposure, is suspected to mediate these adaptive changes. Here, we sought to demonstrate...

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Identifiers

PMID: 20505100
DOI: 10.1523/JNEUROSCI.0252-10.2010
PMCID: PMC2888489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Striatal overexpression of DeltaFosB reproduces chronic levodopa-induced involuntary movements.PMID 20505100Read ↗

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