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Article

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.

Neurobiology of disease - 1 Oct 2005

Klein Ronald L, Dayton Robert D, Lin Wen-Lang, Dickson Dennis W

Abstract excerpt

Using a viral vector for mutant (P301L) tau, we studied the effects of gene transfer to the rat substantia nigra in terms of structural and functional properties of dopaminergic neurons. The mutant tau vector caused progressive loss of pars compacta dopaminergic neurons over time, reduced striatal dopamine content, and amphetamine-stimulated rotational behavior consistent with a specific lesion effect. In...

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Identifiers

PMID: 16137567
DOI: 10.1016/j.nbd.2005.02.001
PMCID: PMC2975329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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