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Article

Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture.

PLoS pathogens - 20 May 2010

Silberstein Erica, Mihalik Kathleen, Ulitzky Laura, Plant Ewan P, Puig Montserrat, Gagneten Sara, Yu Mei-ying W, Kaushik-Basu Neerja, Feinstone Stephen M, Taylor Deborah R

Abstract excerpt

HCV (hepatitis C virus) research, including therapeutics and vaccine development, has been hampered by the lack of suitable tissue culture models. Development of cell culture systems for the growth of the most drug-resistant HCV genotype (1b) as well as natural isolates has remained a challenge. Transfection of cultured cells with adenovirus-associated RNA(I) (VA RNA(I)), a known interferon (IFN) antagonist and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20502631
DOI: 10.1371/journal.ppat.1000910
PMCID: PMC2873922

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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