Article
Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.
The Journal of antimicrobial chemotherapy - 1 Jul 2010
Wurtz Nathalie, Briolant Sébastien, Gil Marine, Parquet Véronique, Henry Maud, Baret Eric, Amalvict Rémy, Almeras Lionel, Rogier Christophe, Pradines Bruno
Abstract excerpt
OBJECTIVES: The aim of the study was to assess the in vitro potentiating effects of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in combination with mefloquine, chloroquine or monodesethylamodiaquine against Plasmodium falciparum and to evaluate whether the effects of atorvastatin could be associated with mutations or gene copy number in multidrug resistance (MDR)-like...
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