Article
Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.
The Journal of antimicrobial chemotherapy - 1 Jul 2010
Wurtz Nathalie, Briolant Sébastien, Gil Marine, Parquet Véronique, Henry Maud, Baret Eric, Amalvict Rémy, Almeras Lionel, Rogier Christophe, Pradines Bruno
Abstract excerpt
OBJECTIVES: The aim of the study was to assess the in vitro potentiating effects of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in combination with mefloquine, chloroquine or monodesethylamodiaquine against Plasmodium falciparum and to evaluate whether the...
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