Article
Plasmodium falciparum proteome changes in response to doxycycline treatment.
Malaria journal - 25 May 2010
Briolant Sébastien, Almeras Lionel, Belghazi Maya, Boucomont-Chapeaublanc Elodie, Wurtz Nathalie, Fontaine Albin, Granjeaud Samuel, Fusaï Thierry, Rogier Christophe, Pradines Bruno
Abstract excerpt
BACKGROUND: The emergence of Plasmodium falciparum resistance to most anti-malarial compounds has highlighted the urgency to develop new drugs and to clarify the mechanisms of anti-malarial drugs currently used. Among them, doxycycline is used alone for malaria chemoprophylaxis or in combination with quinine or artemisinin derivatives for malaria treatment. The molecular mechanisms of doxycycline action in P....
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