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Proteomic analysis reveals differential responses to praziquantel in two Schistosoma mansoni strains with distinct phenotypes.

Molecular and biochemical parasitology - 1 Dec 2025

Valentini Marilia Bergamini, Mendes Tiago Manuel Fernandes, Cabral Fernanda Janku, Allegretti Silmara Marques

Abstract excerpt

Different Schistosoma mansoni strains may exhibit distinct phenotypes, which can influence parasite distribution, treatment outcomes, and control strategies. In this study, we conducted a label-free quantitative proteomic analysis to compare two strains of S. mansoni, Belo Horizonte (SmBH) and Sergipe (SmSE), which differ in phenotypic traits and susceptibility to praziquantel (PZQ). BALB/c mice were infected and...

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PMID: 41151641
DOI: 10.1016/j.molbiopara.2025.111709

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