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Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite <i>Plasmodium falciparum</i>

28 Aug 2006

Abstract excerpt

Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, the apicoplast and the mitochondrion, in cultured Plasmodium falciparum. Antimalarial effects were much greater after...

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PMID: 16940111
DOI: 10.1128/aac.00394-06

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