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Article

Interleukin-1 cluster gene polymorphisms and aneurysmal subarachnoid hemorrhage.

Neurosurgery - 1 Jun 2010

Fontanella Marco, Rainero Innocenzo, Gallone Salvatore, Rubino Elisa, Fornaro Riccardo, Fenoglio Pierpaola, Valfrè Walter, Vaula Giovanna, Benevello Chiara, Ducati Alessandro, Pinessi Lorenzo

Abstract excerpt

BACKGROUND: Emerging data indicate that proinflammatory cytokines may be involved in the pathogenesis of intracranial aneurysms. Interleukin (IL)-1 is a proinflammatory cytokine that plays a pivotal role in both acute and chronic central nervous system injuries. OBJECTIVE: To investigate whether select polymorphisms in the IL-1alpha, IL-1beta, and IL-1 receptor antagonist genes are associated with both...

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PMID: 20495422
DOI: 10.1227/01.NEU.0000369187.95163.5D

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