Article
Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine.
Journal of neurochemistry - 1 Aug 2010
Li Yan, Cheng Shu-Yuan, Chen Nianhang, Reith Maarten E A
Abstract excerpt
Our previous work suggested a role for oligomerization in regulating dopamine transporter (DAT) internalization, with d-amphetamine dissociating DAT oligomers and monomers being endocytosed. This model was put to detailed testing in the present work with the use of DAT constructs differentially tagged with Myc or Flag, reversal of tags in co-immunoprecipitation and cross-linking assays, and application of...
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