Article
Somatic mutation and aging.
Annals of the New York Academy of Sciences - 20 Nov 1998
Morley A
Abstract excerpt
A key prediction of the somatic mutation theory of aging is that there is an invariant relationship between life span and the number of random mutations. A number of studies at a number of gene loci have shown that somatic mutations of a variety of types accumulate with age. Dietary restriction,...
Topics
- Aging
- Animals
- HLA-A Antigens
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Longevity
- Lymphocytes
- Mice
- Mice, Mutant Strains
- Models, Genetic
- Mutation