Article
Somatic mutation and aging.
Annals of the New York Academy of Sciences - 20 Nov 1998
Morley A
Abstract excerpt
A key prediction of the somatic mutation theory of aging is that there is an invariant relationship between life span and the number of random mutations. A number of studies at a number of gene loci have shown that somatic mutations of a variety of types accumulate with age. Dietary restriction, which prolongs life span, results in slowed accumulation of HPRT mutants in mice. Conversely, senescence-accelerated...
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