Article
Common genetic variants near the Brittle Cornea Syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness.
PLoS genetics - 13 May 2010
Lu Yi, Dimasi David P, Hysi Pirro G, Hewitt Alex W, Burdon Kathryn P, Toh Tze'Yo, Ruddle Jonathan B, Li Yi Ju, Mitchell Paul, Healey Paul R, Montgomery Grant W, Hansell Narelle, Spector Timothy D, Martin Nicholas G, Young Terri L, Hammond Christopher J, Macgregor Stuart, Craig Jamie E, Mackey David A
Abstract excerpt
Central corneal thickness (CCT), one of the most highly heritable human traits (h(2) typically>0.9), is important for the diagnosis of glaucoma and a potential risk factor for glaucoma susceptibility. We conducted genome-wide association studies in five cohorts from Australia and the United Kingdom (total N = 5058). Three cohorts were based on individually genotyped twin collections, with the remaining two...
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