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Article

Mutations in the zinc finger protein gene, ZNF469, contribute to the pathogenesis of keratoconus.

Investigative ophthalmology & visual science - 5 Aug 2014

Vincent Andrea L, Jordan Charlotte A, Cadzow Murray J, Merriman Tony R, McGhee Charles N

Abstract excerpt

PURPOSE: Mutations in the zinc finger protein gene ZNF469 cause recessive brittle cornea syndrome, characterized by spontaneous corneal perforations. Genome-wide association studies (GWAS) have implicated common variants in this gene as a determinant for central corneal thickness (CCT). We investigated the contribution of ZNF469 in a sample set of keratoconus patients. METHODS: Forty-three patients with...

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PMID: 25097247
DOI: 10.1167/iovs.14-14532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the zinc finger protein gene, ZNF469, contribute to the pathogenesis of keratoconus.PMID 25097247Read ↗

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