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Article

The contributory role of angiotensin receptor-like 1 gene multiple polymorphisms in hypertension among northeastern Han Chinese.

PloS one - 1 Jan 2014

Liu Ruoshan, Zhao Hongye, Wang Yuefei, Wang Yanli, Lu Changzhu, Xiao Yu, Jia Nan, Wang Bin, Niu Wenquan

Abstract excerpt

BACKGROUND AND OBJECTIVE: Via direct sequencing, we have recently identified six common polymorphisms in angiotensin receptor-like 1 (AGTRL1) gene, and found only two polymorphisms were significantly associated with hypertension in a family-based analysis on 1,015 southern Han Chinese. Extending our previous work and considering the ubiquity of epistasis in determining disease susceptibility, we, in this study,...

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PMID: 24465893
DOI: 10.1371/journal.pone.0086095
PMCID: PMC3896457

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