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Article

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 May 2010

Wan Jun, Fu Amy K Y, Ip Fanny C F, Ng Ho-Keung, Hugon Jacques, Page Guylène, Wang Jerry H, Lai Kwok-On, Wu Zhenguo, Ip Nancy Y

Abstract excerpt

One of the pathological hallmarks of Alzheimer's disease (AD) is deposition of extracellular amyloid-beta (Abeta) peptide, which is generated from the cleavage of amyloid precursor protein (APP). Accumulation of Abeta is thought to associate with the progressive neuronal death observed in AD. However, the precise signaling mechanisms underlying the action of Abeta in AD pathophysiology are not completely...

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Identifiers

PMID: 20484629
DOI: 10.1523/JNEUROSCI.0519-10.2010
PMCID: PMC6632652

Genes

STAT3
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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