Article
Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish.
Gastroenterology - 1 Mar 2014
Choi Tae-Young, Ninov Nikolay, Stainier Didier Y R, Shin Donghun
Abstract excerpt
BACKGROUND & AIMS: Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investigate this issue, we established a zebrafish model of liver regeneration in which the extent of...
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