Article
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2010
McFarland-Mancini Molly M, Funk Holly M, Paluch Andrew M, Zhou Mingfu, Giridhar Premkumar Vummidi, Mercer Carol A, Kozma Sara C, Drew Angela F
Abstract excerpt
IL-6 modulates immune responses and is essential for timely wound healing. As the functions mediated by IL-6 require binding to its specific receptor, IL-6Ralpha, it was expected that mice lacking IL-6Ralpha would have the same phenotype as IL-6-deficient mice. However, although IL-6Ralpha-deficient mice share many of the inflammatory deficits seen in IL-6-deficient mice, they do not display the delay in wound...
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