Article
T cell-mediated help against tumors.
Cell cycle (Georgetown, Tex.) - 1 Oct 2008
Wieder Thomas, Braumüller Heidi, Kneilling Manfred, Pichler Bernd, Röcken Martin
Abstract excerpt
Adoptive transfer of tumor antigen-specific T helper (Th) cells is a surprisingly potent anti-tumor therapy. Even in RIP1-Tag2 mice with a rapidly growing, aggressive endogenous beta cell tumor Th can significantly extend life time and are more efficient than any other therapy studied. The therapeutic effect of Th cells seems to be independent of tumor cell destruction. It critically relies on three principles:...
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