Article
Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2010
Noton Sarah L, Cowton Vanessa M, Zack Chadene R, McGivern David R, Fearns Rachel
Abstract excerpt
RNA virus polymerases must initiate replicative RNA synthesis with extremely high accuracy to maintain their genome termini and to avoid generating defective genomes. For the single-stranded negative-sense RNA viruses, it is not known how this accuracy is achieved. To investigate this question, mutations were introduced into the 3' terminal base of a respiratory syncytial virus (RSV) template, and the RNA...
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