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Article

Lethal mutagenesis in viruses and bacteria.

Genetics - 1 Oct 2009

Chen Peiqiu, Shakhnovich Eugene I

Abstract excerpt

In this work we study how mutations that change physical properties of cell proteins (stability) affect population survival and growth. We present a model in which the genotype is presented as a set folding free energies of cell proteins. Mutations occur upon replication, so stabilities of some p...

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Identifiers

PMID: 19620390
DOI: 10.1534/genetics.109.106492
PMCID: PMC2766323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19620390-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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