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Article

Prospectively Identified Incident Testicular Cancer Risk in a Familial Testicular Cancer Cohort.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2015

Pathak Anand, Adams Charleen D, Loud Jennifer T, Nichols Kathryn, Stewart Douglas R, Greene Mark H

Abstract excerpt

BACKGROUND: Human testicular germ cell tumors (TGCT) have a strong genetic component and a high familial relative risk. However, linkage analyses have not identified a rare, highly penetrant familial TGCT (FTGCT) susceptibility locus. Currently, multiple low-penetrance genes are hypothesized to underlie the familial multiple-case phenotype. The observation that two is the most common number of affected...

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PMID: 26265202
DOI: 10.1158/1055-9965.EPI-14-1240
PMCID: PMC4592450

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