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Article

Alkyl isocyanides serve as transition state analogues for ligand entry and exit in myoglobin.

Biochemistry - 22 Jun 2010

Blouin George C, Schweers Rachel L, Olson John S

Abstract excerpt

Alkyl isocyanides (CNRs) identify pathways for diatomic ligand movement into and out of Mb, with their side chains acting as transition state analogues. The bound alkyl groups point either into the back of the distal pocket (in conformation, nu(CN) approximately 2070-2090 cm(-1)), which allows hydrogen bond donation from His64(E7) to the isocyano group, or toward solvent through an open His(E7) channel (out...

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Identifiers

PMID: 20476741
DOI: 10.1021/bi1001745
PMCID: PMC4102008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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