Article
Ligand pathways in myoglobin: a review of Trp cavity mutations.
IUBMB life - 1 Jan 2000
Olson J S, Soman J, Phillips G N
Abstract excerpt
The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three major cavities occupied by photodissociated ligands. In this work, we review the effects of the...
Topics
- Crystallography, X-Ray
- Ligands
- Mutation
- Myoglobin
- Recombination, Genetic
- Tryptophan
