Article
Alkylamine-ligated H93G myoglobin cavity mutant: a model system for endogenous lysine and terminal amine ligation in heme proteins such as nitrite reductase and cytochrome f.
Inorganic chemistry - 21 Feb 2011
Du Jing, Perera Roshan, Dawson John H
Abstract excerpt
His93Gly sperm whale myoglobin (H93G Mb) has the proximal histidine ligand removed to create a cavity for exogenous ligand binding, providing a remarkably versatile template for the preparation of model heme complexes. The investigation of model heme adducts is an important way to probe the relationship between coordination structure and catalytic function in heme enzymes. In this study, we have successfully...
Topics
- Alkylation
- Amines
- Animals
- Binding Sites
- Catalysis
- Circular Dichroism
- Cytochromes f
- Glycine
- Histidine
- Ligands
- Lysine
- Models, Biological
- Mutation
- Myoglobin
- Nitrite Reductases