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Article

Water and ligand entry in myoglobin: assessing the speed and extent of heme pocket hydration after CO photodissociation.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006

Goldbeck Robert A, Bhaskaran Shyam, Ortega Cheri, Mendoza Juan L, Olson John S, Soman Jayashree, Kliger David S, Esquerra Raymond M

Abstract excerpt

A previously undescribed spectrokinetic assay for the entry of water into the distal heme pocket of wild-type and mutant myoglobins is presented. Nanosecond photolysis difference spectra were measured in the visible bands of sperm whale myoglobin as a function of distal pocket mutation and temperature. A small blue shift in the 560-nm deoxy absorption peak marked water entry several hundred nanoseconds after CO...

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Identifiers

PMID: 16432219
DOI: 10.1073/pnas.0507840103
PMCID: PMC1360539

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