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Article

Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes

1 Oct 2007

Abstract excerpt

A relationship between inactivation of mitotic checkpoint genes and sensitivity of cancer cells to anticancer agents has been reported. We investigated the effect of epigenetic inactivation by aberrant hypermethylation of the mitotic checkpoint gene CHFR (checkpoint with forkhead and ring finger) on the sensitivity of cervical cancer cells to taxanes. Methylation-specific PCR (MSP) of cervical smears showed...

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Identifiers

PMID: 17786301
DOI: 10.3892/ijo.31.4.713

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