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Article

Cell cycle regulation and p53 activation by protein phosphatase 2C alpha.

The Journal of biological chemistry - 18 Apr 2003

Ofek Paula, Ben-Meir Daniella, Kariv-Inbal Zehavit, Oren Moshe, Lavi Sara

Abstract excerpt

Protein phosphatase 2C (PP2C) dephosphorylates a broad range of substrates, regulating stress response and growth-related pathways in both prokaryotes and eukaryotes. We now demonstrate that PP2C alpha, a major mammalian isoform, inhibits cell growth and activates the p53 pathway. In 293 cell clones, in which PP2C alpha expression is regulated by a tetracycline-inducible promoter, PP2C alpha overexpression led to...

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PMID: 12514180
DOI: 10.1074/jbc.M211699200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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