Article
Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway.
Molecular cell - 14 May 2010
Talarek Nicolas, Cameroni Elisabetta, Jaquenoud Malika, Luo Xuan, Bontron Séverine, Lippman Soyeon, Devgan Geeta, Snyder Michael, Broach James R, De Virgilio Claudio
Abstract excerpt
Eukaryotic cell proliferation is controlled by growth factors and essential nutrients, in the absence of which cells may enter into a quiescent (G(0)) state. In yeast, nitrogen and/or carbon limitation causes downregulation of the conserved TORC1 and PKA signaling pathways and, consequently, activation of the PAS kinase Rim15, which orchestrates G(0) program initiation and ensures proper life span by controlling...
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