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Article

TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.

Molecular cell - 1 Dec 2003

Pedruzzi Ivo, Dubouloz Frédérique, Cameroni Elisabetta, Wanke Valeria, Roosen Johnny, Winderickx Joris, De Virgilio Claudio

Abstract excerpt

The highly conserved Tor kinases (TOR) and the protein kinase A (PKA) pathway regulate cell proliferation in response to growth factors and/or nutrients. In Saccharomyces cerevisiae, loss of either TOR or PKA causes cells to arrest growth early in G(1) and to enter G(0) by mechanisms that are poorly understood. Here we demonstrate that the protein kinase Rim15 is required for entry into G(0) following...

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PMID: 14690612
DOI: 10.1016/s1097-2765(03)00485-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.PMID 14690612Read ↗

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Genetic interaction profiles of regulatory kinases differ between environmental conditions and cellular states.Semantic proximity Read ↗

Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase.Semantic proximity Read ↗

The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.Semantic proximity Read ↗

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.Semantic proximity Read ↗

To divide or not to divide: a key role of Rim15 in calorie-restricted yeast cultures.Semantic proximity Read ↗

Type 2C protein phosphatases (PP2Cs) regulate cell proliferation in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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