Article
Posttranscriptional Regulation of Gcr1 Expression and Activity Is Crucial for Metabolic Adjustment in Response to Glucose Availability.
Molecular cell - 5 May 2016
Hossain Munshi Azad, Claggett Julia M, Edwards Samantha R, Shi Aishan, Pennebaker Sara L, Cheng Melodyanne Y, Hasty Jeff, Johnson Tracy L
Abstract excerpt
The transcription factor Gcr1 controls expression of over 75% of the genes in actively growing yeast. Yet despite its widespread effects, regulation of Gcr1 itself remains poorly understood. Here, we show that posttranscriptional Gcr1 regulation is nutrient dependent. Moreover, GCR1 RNA contains a long, highly conserved intron, which allows the cell to generate multiple RNA and protein isoforms whose levels...
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