Article
Trends in HIV-1 reverse transcriptase resistance-associated mutations and antiretroviral prescription data from 2003-2010.
Antiviral therapy - 1 Jan 2012
Miller Michael D, Haddad Mojgan, Su Cathy, Gibbs Craig, McColl Damian J, Guyer Bill
Abstract excerpt
BACKGROUND: The selection of antiretroviral (ARV) drugs for treatment of HIV-1 infection is based on several factors including potency, toxicity, resistance and ease of administration. Emtricitabine (FTC) or lamivudine (3TC), components of recommended initial ARV regimens, are structurally related and share the same resistance mutation (M184V/I). However they differ with respect to potency and incidence of...
Topics
- Adenine
- Anti-HIV Agents
- Deoxycytidine
- Drug Prescriptions
- Drug Resistance, Viral
- Drug Therapy, Combination
- Emtricitabine
- Genotype
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Lamivudine
- Mutation
- Organophosphonates
- Prevalence
- Reverse Transcriptase Inhibitors
- Tenofovir