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SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

11 May 2010

Abstract excerpt

Congestive heart failure (HF) is associated with impaired endothelium-dependent nitric oxide-mediated vasodilatation. The aim of this study was to examine the effects of sarco/endoplasmic reticulum (ER) Ca(2+)-ATPase 2a (SERCA2a) gene transfer on endothelial function in a swine HF model. Two months after the creation of mitral regurgitation to induce HF, the animals underwent intracoronary injection of...

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PMID: 20461063
DOI: 10.1038/mt.2010.77

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